I-O International Immuno-Oncology Network, created in 2012 (United States), from 496 sister brands and 17477 competing brands. I-O International Immuno-Oncology Network's notoriety arose from exemplary management which optimizes product quality and client satisfaction, which in turn generate financial performance, and therefore, stock performance. Being a Popular brand online is assessed based on the evolution of worldwide Web searches over the last five years.